Study of Lipid Profile in Patients of Hypothyroidism And Correlation with Incidence of Gallston
IOSR Journal of Dental and Medical Sciences
Thyroid hormones influences lipid metabolism, rise in serum cholesterol in hypothyroidism causes supersaturation of bile leading to depressed gall bladder contractility, hence risk of gall stone formation so we tries to correlate these changes. Material and methods: The present study has been conducted in . Present study comprised of 105 patients with hypothyroidism attending OPD and medicine ward. They were examined thoroughly after history taking and then subjected to routine investigation
... ne investigation with special emphasis on lipid profile, thyroid profile and USG abdomen especially gall bladder and hepatobiliary. Association of gall bladder stone and hypothyroidism was also observed. Patients with TSH level > 5.5 were considered to having hypothyroidism, thus cases were divided into two groups. Group I with TSH level between 5.5 to 10 IU/ml (Subclinical hypothyroidism) and Group II with TSH level above 10 IU/ml (Overt hypothyroidism). Results : Prevalence of hypothyroidism was maximum between 20-60 years age group patients (77.23%). Most cases occurred in females (82 females and 23 males). Most common symptoms in female was tiredness (58 i.e. 70.73%) then weight gain (52 i.e. 63.41%), cold intolerance (47 i.e. 57.31%), constipation. Most common sign dry coarse skin (79.26%) followed by edema (67.0%). While in male patients most common symptom is tiredness (16 i.e. 69.56%) followed by cold intolerance (11 i.e. 47.82%), weight gain (10 i.e. 43.47%). Most common sign was edema (69.56%) and then dry coarse skin (60.86%). These clinical features were more in overt hypothyroidism compared to subclinical hypothyroidism in both sexes. Abnormal lipid profile was seen in both overt hypothyroidism (29/49 i.e. 59.18%) and subclinical hypothyroidism patients (28/56 i.e. 50%). Abnormal total cholesterol, TG, LDL, VLDL was seen in 35.1%, 27.0%, 8.1% and 13.5% respectively in overt hypothyroidism female patients while in subclinical hypothyroidism female patients it was 28.8%, 24.4%, 8.8%, 11.1% and 15.5% respectively. There is significant increase in total cholesterol and LDL cholesterol and decrease in HDL cholesterol. Prevalence of cholelithiasis was more in subclinical hypothyroidism compared to overt hypothyroidism which was 15/56 (26.78%) and 7/49 (14.28%) respectively, that too more in female compared to male, thus showing strong association between them. Conclusion: Hypothyroidism is associated with dyslipidemia, cholelithiasis is significantly associated with subclinical hypothyroidism.