Effects of Artemisia princeps Extract on Bone Metabolism
애엽 추출물이 골 대사에 미치는 영향

Seung-Min Lee, Myung-Gyou Kim, Seung-Youn Lee, Tae-Hoon Kang
2010 Journal of the Korean Society of Food Science and Nutrition  
Artemisia princeps has been utilized as a traditional medicine for a variety of diseases in Korea. In this study, we investigated the effects of Artemisia princeps extract (APE) on bone metabolism both in vitro using primary mouse bone marrow-derived macrophage and in vivo using ovariectomized rats. APE decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells and TRAP activity. Also, APE inhibited bone resorptive activity of differentiated osteoclasts. In
more » ... ted osteoclasts. In ovariectomized rats, APE alleviated the decrease in the trabecular bone mineral density. These results showed that APE might be useful for the prevention of postmenopausal bone loss.
doi:10.3746/jkfn.2010.39.3.363 fatcat:qi3gtadqhrd6xc7pxd3ihpkmha