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Are Antisense Proteins in Prokaryotes Functional?
2020
Frontiers in Molecular Biosciences
Many prokaryotic RNAs are transcribed from loci outside of annotated protein coding genes. Across bacterial species hundreds of short open reading frames antisense to annotated genes show evidence of both transcription and translation, for instance in ribosome profiling data. Determining the functional fraction of these protein products awaits further research, including insights from studies of molecular interactions and detailed evolutionary analysis. There are multiple lines of evidence,
doi:10.3389/fmolb.2020.00187
pmid:32923454
pmcid:PMC7457138
fatcat:zjo6vf7xwncpbcugtkl3ld6cra