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Interferon- -Oligodendrocyte Interactions in the Regulation of Experimental Autoimmune Encephalomyelitis
2007
Journal of Neuroscience
Experimental autoimmune encephalomyelitis (EAE) is an animal model of the human demyelinating disorder multiple sclerosis (MS). The immune cytokine interferon-gamma (IFN-gamma) is believed to participate in disease pathogenesis in both EAE and MS. In the present study, we examined the significance of IFN-gamma-oligodendrocyte interactions in the course of EAE. For the purpose of our study, we used the previously described [proteolipid protein/suppressor of cytokine signaling 1 (PLP/SOCS1)]
doi:10.1523/jneurosci.4689-06.2007
pmid:17314297
pmcid:PMC6673565
fatcat:qjaknsd7lvhelgrjwzw3hywpuu