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The role for 11-oxygenated androgens in HPG-axis disturbances in congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Context Hypothalamus-pituitary-gonadal (HPG)-axis disturbances are a common phenomenon in patients with classic congenital adrenal hyperplasia (CAH). 11-oxygenated androgens have been suggested to play a role in this context. Design Cross-sectional single center study including 89 patients (N=42 men, N=55 women) with classic CAH. Main Outcome Measures Independent predictors for hypogonadism in men and secondary amenorrhea in women with CAH with a special focus on 11-ketotestosterone (11KT) anddoi:10.1101/2021.01.13.21249718 fatcat:rounynnj5fgqrpalr2yxfp6aly