Epidemiology of EV71 Outbreaks in the Region in the Past Decade

A. Kiyu, J. Cardosa, K. Mohd-Noh, R. Matbah, C.H. Ooi
2008 International Journal of Infectious Diseases  
help define the optimal drug exposure associated with treatment efficacy. The analyses of data from experimental models with different antifungal drug classes have identified distinct pharmacodynamic characteristics. Results from these models have been useful for defining the relationship between antifungal exposures and efficacy. More recently clinical data has become available allowing similar investigation. These results of these studies have been similar to those from experimental models
more » ... erimental models and have cemented the clinical significance of these pharmacodynamic concepts. The analyses have been shown to be helpful for the design of antifungal dosing intervals, choice of optimal dose levels, therapeutic drug monitoring, and the development of susceptibility breakpoints. Most of these preclinical and clinical studies have targeted therapeutic efficacy against Candida species. More recent studies have also considered other fungal pathogens and have begun to investigate the role of anifungal pharmacodynamics and drug resistance development. Although there remain many unanswered questions regarding antifungal pharmacodynamics, available data suggest usefulness in the application of pharmacodynamics to help guide antifungal therapy.
doi:10.1016/j.ijid.2008.05.074 fatcat:plimnmduzzev3n3sxtyz7ny2ou