Dacrymenone and VM 3298-2--new antibiotics with antibacterial and antifungal activity

Viktor Mierau, Timm Anke, Olov Sterner
Zeitschrift fur Naturforschung. Section C, Biosciences  
Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.
pmid:12939041 fatcat:ohqf3jrisrgtpmrc5fnbg7aedq