Possible mechanisms underlying acceleration of proliferation by 15-deoxy-.DELTA.12,14-prostaglandin J2 and the precursors in human T acute lymphoblastic leukemia cell line CCRF-CEM
ヒト急性リンパ芽球性白血病細胞株CCRF-CEMにおける15-deoxy-Δ12, 14-prostaglandin J2および前駆体による増殖能促進メカニズム

YASUTAKA AZUMA, KYOKO WATANABE, MASATAKA DATE, SHINYA SHIRASU, MICHIHARU DAITO, KIYOSHI OHURA
2003 ORAL THERAPEUTICS AND PHARMACOLOGY  
15-Deoxy-4 12,14-prostaglandin J2 (15dPGJ2 ), that is a ligand for peroxisome proliferator-activated receptor ƒÁ (PPAR ƒÁ), induced apoptosis of human p18, p21, p27 in CCRF-CEM. These results suggest that PGD2, PGJ2, 4 PGJ2 and 15dPGJ2 may, through the activation of p38 MAPK and/or PI3K, potentiate the expression of cyclin A, leading to acceleration of proliferation in CCRF-CEM.
doi:10.11263/jsotp1982.22.160 fatcat:q4mxhcde3befvdx5cuztfs2rm4