molecular biology as a very important source of information o recent development in tumor biology and treatment of huma malignant melanoma. M. Micksche, Vienn Incidence of malignant melanoma has increased dramatically during the last decades. Therefore comprehensive information on basic and clinical aspects of this malignant disease -as presented in this monograph -is most important for the medical community. Almost all authorities in the field of malignant melanoma research have contributed to
... this book. The different chapters deal with basic biology, natural history and clinical management of the disease. All these contributions are of great value and present a very recent update of today's knowledge. The overview on the role of oncogenes in the pathogenesis of malignant melanoma analyzes the status of oncogene expression during specific clinically defined stages of the disease. Furthermore the question whether multiple, cooperating, independently achivated oncogenes are involved in the evolution of malignant melanoma is elaborated. Another article deals with the expression of certain matrix proteins such as laminin and fibronectin by melanoma cells which obviously appear to modulate their metastatic behavior. The structure, function and biosynthesis of tumor associate antigens (TAA) such as ganglioside antigens in neuroectodermal human tumors is described in a further chapter. Most interesting, the use of monoclonal antibodies reacting with these TAA for treatment of human xenografts in the nude mouse model. In 2 different chapter on the natural history of malignant melanoma, data on the epidemiology of ocular melanoma, on prognostic factors and also on endocrine influences on the disease outcome are presented. The studies on psychosocial factors in relation to development and outcome of cutaneous melanoma have been conducted by an interdisciplinary research group, which highlights the actuality of this book on several aspects of the disease. These studies include the association of psychosocial factors with prognostic indicators, with the delay in setting medical attention, with tumor host predilection response and with styles of coping and their relationship in disease progression. The problem of the very clear predilection for spread of melanoma to the central nervous system, including the treatment modalities for those metastatic sites, arc presented in a very comprehensive way. Finally, in the therapy part of this book an overview on interferon therapy is given and the use of fast neutrons for treatment of malignant melanoma is very informatively reviewed.