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Insights into the Importance of WPD-Loop Sequence for Activity and Structure in Protein Tyrosine Phosphatases
2022
Chemical Science
Preserved Fulltext
Protein tyrosine phosphatases (PTPs) possess a conserved mobile catalytic loop, the WPD-loop, which brings an aspartic acid into the active site where it acts as an acid/base catalyst. Prior experimental...
doi:10.1039/d2sc04135a
pmid:36507179
pmcid:PMC9682893
fatcat:txiyqhomwfh4fgudpm74ed6hg4