Insights into the Importance of WPD-Loop Sequence for Activity and Structure in Protein Tyrosine Phosphatases

Ruidan Shen, Rory M. Crean, Keith J. Olsen, Marina Corbella, Ana Rita Calixto, Teisha Richan, Tiago A. S. Brandão, Ryan D. Berry, Alex Tolman, Patrick Loria, Sean Johnson, Shina Caroline Lynn Kamerlin (+1 others)
2022 Chemical Science  
Protein tyrosine phosphatases (PTPs) possess a conserved mobile catalytic loop, the WPD-loop, which brings an aspartic acid into the active site where it acts as an acid/base catalyst. Prior experimental...
doi:10.1039/d2sc04135a pmid:36507179 pmcid:PMC9682893 fatcat:txiyqhomwfh4fgudpm74ed6hg4