OncodriveFML: a general framework to identify coding and non-coding regions with cancer driver mutations

Loris Mularoni, Radhakrishnan Sabarinathan, Jordi Deu-Pons, Abel Gonzalez-Perez, Núria López-Bigas
2016 Genome Biology  
Distinguishing the driver mutations from somatic mutations in a tumor genome is one of the major challenges of cancer research. This challenge is more acute and far from solved for non-coding mutations. Here we present OncodriveFML, a method designed to analyze the pattern of somatic mutations across tumors in both coding and non-coding genomic regions to identify signals of positive selection, and therefore, their involvement in tumorigenesis. We describe the method and illustrate its
more » ... s to identify protein-coding genes, promoters, untranslated regions, intronic splice regions, and lncRNAs-containing driver mutations in several malignancies.
doi:10.1186/s13059-016-0994-0 pmid:27311963 pmcid:PMC4910259 fatcat:whg3hamnbjgq5d23kuztyr2pdq