PL-010 Turmeric enema: a novel therapy for C. difficile colitis (CDAD): A randomized, double blinded, placebo controlled prospective clinical trial

P.P. Basu, N. Krishnaswamy, N.J. Shah, T. Nair, S. Farhat, L. Ang
2011 International Journal of Infectious Diseases  
Objective: To investigate antibiotic multi-drug resistance of Neisseria gonorrhoeae (N. gonorrhoeae) strains isolated from the local female patients and the role of plasmidmediated on resistance of N. gonorrhoeae. Methods: Antimicrobial susceptibility of N. gonorrhoeae to various antibiotics was analysed by K-B disk diffusion method, and strains of multi-drug resistance were screened out. The agar-dilution method was used to determine the minimum inhibitory concentration (MIC) of three
more » ... ) of three antibiotics including Penicillin-G, Tetracycline, Ciprofloxacin. It was also compared that MIC of three antibiotics to PPNG positive and PPNG negative strains. Extraction and analysis of the plasmids in 69 N. gonorrhoeae were determined by alkalinelysis and Sepharose electrophoresis technic. Results: 58 multi-drug resistance strains (67.44%) were obtained by the K-B method. There were 15 strains (17.44%) to 4 antibiotics, 9 strains (10.47%) to 5 antibiotics, 23 strains (26.74%) to 6 antibiotics and 11 strains (12.79%) to 7 antibiotics resistance among N.gonorrhoeae strains. The MIC 90 for penicillin, tetracycline and ciprofloxacin to PPNG positive strains were 64.0, 32.0, 32.0mg/ml and 8.0, 16.0, 2.0 mg/ml to negative strains, respectively. Four types of the plasmid with 4.2Kb, 7.4Kb, 39.5Kb and 42.5Kb molecular weighe were found among 69 N. gonorrhoeae strains. The plasmid profiles types of 39.5kb (24.63%) and 39.5 + 42.5kb (13.04%) were prominent. Conclusion: The study showed that the mult-resistance of N. gonorrhoeae in female patients was severe. Resistant plasmids transfered easily among N. gonorrhoeae strains. And the plasmids of 39.5Kb and 7.4Kb were relative with penicillin resistance. OL-071 Interaction between Hepatitis C and HIV infected patients
doi:10.1016/s1201-9712(11)60136-7 fatcat:kbnim2hbyvhd3gk5nczm4sxkc4