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Structural basis for the binding selectivity of human CDY chromodomains
[article]
2019
bioRxiv
pre-print
The CDY (Chromodomain on the Y) family is a small family of chromodomain containing proteins, whose chromodomains closely resemble those in HP1 and Polycomb. The CDY proteins play an essential role in normal spermatogenesis and brain development. Dysregulation of their expression has been linked to male infertility and various neurological diseases. Like the chromodomains of HP1 and Polycomb, the CDY chromodomains also recognize the lysine-methylated ARKS motif embedded in histone and
doi:10.1101/820647
fatcat:up5vlzmmwnbtbih2ig6dxtub3m