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New Avenues in the LRP5-mediated Bone Mass Acquisition
2012
Korean Journal of Bone Metabolism
Lipoprotein receptor-related protein (LRP5) signaling is well correlated with the bone mass in both human and mice. Loss-of-function mutations of LRP5 result in osteopenia or osteoporosis. In contrast, gain-of-function mutations show high bone mass phenotype. To elucidate the molecular mechanism of the LRP5-mediated bone mass acquisition, several groups have genetically dissected the Wingless and Int-1 (Wnt) -catenin signaling pathway using osteoblast-lineage specific Cre mice. Key players for
doi:10.11005/kjbm.2012.19.1.1
fatcat:254dr5xszrds3flrgf2ylonz7a