Chronic pain may be related to a set of biological-psychological-social factors.The purpose of this study was to investigate the relationships betweendepression, pain selfefficacy ,physical disability andchronic pain. Method and Instruments: This study hada descriptive -correlational method. In this study 100 patient with chronic pain who were referred to pain clinics in Tehran (2018) were studied.The sample was selected by purposive sampling method. The participants completed the physical

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... ility questionnaire, pain self-efficacy questionnaire, Beck depression inventory and pain history questionnaire. To test the hypotheses,Pearson correlation and multiple regression tests were used. Data were analyzed by SPSS-25. Findings: Depression, pain self-efficacy and physical disability inpatient with chronic pain were assessed. According to the results of this study, 9.6% of the variance in chronic pain in patient with chronic painwere explained by depression, pain self-efficacy and physical disability. Conclusion:To conclude, it seems that chronic pain is affected by some psychological and physiological factors as depression and self-efficacy and physical disabilities.