Study of oxidative stress and antioxidants among pre eclamptic pregnant women

Bhanupriya Tammineni, Sowjanya Yerram, Sowjanya Yerram
Aim and Objectives: To study the significance of oxidative stress and antioxidants levels in pre eclampsia patients in comparison with normotensive pregnant women. Materials and Methods: Cross sectional study includes 30 pre eclamptic and 30 healthy pregnant women. Fasting venous blood samples were collected during antepartum period and blood levels of Malondialdehyde, Ascorbic Acid, Uric Acid, Superoxide Dismutase And Glutathione Peroxidase is estimated in both controls and cases. Results: In
more » ... cases. Results: In the preeclamptic group, malondialdehyde, a lipid peroxidation product was significantly increased (p<0.001), while antioxidants ascorbic acid and SOD levels were significantly decreased (p<0.001). The other antioxidant uric acid has increased significantly (p<0.001) and Glutathione Peroxidase has no significant change (p>0.05) when compared to normal pregnant women. Conclusion: An altered antioxidant status in Preeclampsia, a indirect proof for the existence of oxidative stress.