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Genes encoding 45S ribosomal RNA (rDNA) are known for their abundance within eukaryotic genomes and for their unstable copy numbers in response to changes in various genetic and epigenetic factors. Commonly, we understand as epigenetic factors (affecting gene expression without a change in DNA sequence), namely DNA methylation, histone posttranslational modifications, histone variants, RNA interference, nucleosome remodeling and assembly, and chromosome position effect. All these were actuallydoi:10.3389/fpls.2020.593692 pmid:33133121 pmcid:PMC7579416 fatcat:ptsx2pd4hvb3tnlzjdl66pfdva