Genetic and environmental contributions to cholesterol and its subfractions in 11-year-old twins. The Medical College of Virginia Twin Study

J N Bodurtha, C W Chen, M Mosteller, W E Nance, R M Schieken, J Segrest
1991 Arteriosclerosis and Thrombosis A Journal of Vascular Biology  
We conducted a cross-sectional analysis of the genetic and environmental contributions to the variance of lipoprotein cholesterol and its subfractions in children during early adolescence. Univariate path analysis was used to determine the relative contributions of genes, individual environment, and family environment to these measures in 233 11-year-old Caucasian twin pairs. For high density lipoprotein, high density lipoprotein 2 , low density lipoprotein, very low density lipoprotein, and
more » ... lipoprotein, and triglycerides, a model that incorporated genes and individual environmental variation but not common environment was sufficient to explain the variation. Different magnitudes of genetic effects were seen for total cholesterol in boys and girls. High density lipoprotein 3 showed different magnitudes by sex for genetic and individual environmental effect. Intermediate density lipoprotein was the only cholesterol subfraction in which shared, or common, environment was found to make a statistically significant contribution to the variation. (Arteriosclerosis and Thrombosis 1991;ll:844-850)
doi:10.1161/01.atv.11.4.844 fatcat:bnidsgugwzcnhnkcty6strgevm