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Multilayer view of pathogenic SNVs in human interactome through in-silico edgetic profiling
[article]
2018
bioRxiv
pre-print
Non-synonymous mutations linked to the complex diseases often have a global impact on a biological system, affecting large biomolecular networks and pathways. However, the magnitude of the mutation-driven effects on the macromolecular network is yet to be fully explored. In this work, we present an systematic multi-level characterization of human mutations associated with genetic disorders by determining their individual and combined interaction-rewiring, edgetic, effects on the human
doi:10.1101/299891
fatcat:anni3epyxbdsxb6ftrj3nhxiq4