The Properties of Bacterial Adaptation to Mono- and Bis-Quaternary Ammonium Compounds

ATSUSHI TABATA, TAKUYA MAEDA, HIDEAKI NAGAMUNE, HIROKI KOURAI
2003 Biocontrol Science  
The adaptation of bacteria to mono-and bis-type quaternary ammonium compounds (QACs) was carried out and studied. The minimum inhibitory concentration (MIC) of bis-QACs against the bacteria in contact with bis-QACs was nearly the same as that against the control. However, the MIC of mono-QAC against the strains adapted to mono-QAC was higher than that against the control. Moreover, bis-QACs were effective against even the strains adapted to mono-QAC. As the cell surface of the strains adapted
more » ... mono-QAC changed to hydrophilic, the difference in the bacterial adaptation was thought to arise from a potent property of bis-QACs whose antimicrobial characteristics are independent of the change in the cell surface hydrophobicity.
doi:10.4265/bio.8.37 fatcat:ujyvomrd2jh43ju6e375yjoafa