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Development of Catalytic Reactions for Precise Control of Chemoselectivity
Chemical and pharmaceutical bulletin
Catalytic chemoselective reactions of innately less reactive functionalities over more reactive functionalities are described. A cooperative catalyst comprising a soft Lewis acid/hard Brønsted base enabled chemoselective activation of a hydroxyl group over an amino group, allowing for nucleophilic addition to electron-deficient olefins. The reaction could be applicable for a variety of amino alcohols, including pharmaceuticals, without requiring a tedious protection-deprotection process.doi:10.1248/cpb.c21-00092 pmid:34078797 fatcat:4tpcznfqiveuzgfnowuuy27zci