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β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma
[article]
2022
bioRxiv
pre-print
Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation is paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high is prevalent, incurable, and routinely fatal. CIMP-high ACC possess abnormal DNA methylation and frequent β-catenin activating mutations. Here, we demonstrate that ACC differentiation is maintained by a balance between nuclear, tissue-specific β-catenin-containing complexes and the epigenome. On chromatin, β-catenin
doi:10.1101/2022.07.02.497654
fatcat:y6thbs6dbvfsdeyfe2hfoe4pk4