SUBCLINICAL HYPOTHYROIDISM IN METABOLIC SYNDROME AND ROLE OF CRP IN 50 ADULT PATIENTS
Pratik Shah, Hetal Patel, Rupal Dosi
Journal of Evidence Based Medicine and Healthcare
BACKGROUND Metabolic Syndrome (MetS) is generally characterised as a clustering of the abnormal levels of blood lipids (low HDL and high triglycerides), impaired fasting glucose, elevated blood pressure, and excess abdominal obesity. The objectives of the study are-To evaluate presence of Subclinical Hypothyroidism in the study population of the patients with metabolic syndrome. To find out relation between Subclinical Hypothyroidism and different parameters of metabolic syndrome. To evaluate
... ether patients of metabolic syndrome with raised hs-CRP have an increased risk of having hypothyroidism. MATERIALS AND METHODS A total of 50 adult patients who met with inclusion criteria were selected. Patients with metabolic syndrome (MetS) who fulfilled the NCEP-ATP III criteria: 3 out of 5 criteria positive. Patients with liver disorders, renal disorders, congestive cardiac failure, pregnant women, patients on oral contraceptive pills, statins and other medications that alter thyroid functions (e.g. lithium, amiodarone or γ-interferon) were excluded from the study. RESULTS A total of 50 patients of metabolic syndrome were enrolled. Out of which 36 were euthyroid, 3 were overt hypothyroid and 11 were subclinical hypothyroid. Out of 11 patients of subclinical hypothyroidism, 9 were female and 2 were male patients. Out of 28 females, 9 (32%) were SCH while out of 22 males, 2 (9%) were SCH. Out of 50 patients, 3 were overt hypothyroid. All 3 patients had BP >130/85, waist circumference was >88 cm and HDL of <50 mg/dL. In our study, prevalence of subclinical hypothyroidism was 22%, 6% were overt hypothyroid and 72% were euthyroid. In our study, amongst the components of metabolic syndrome, blood pressure >130/85, HDL <50 mg/dL and waist circumference criteria were more associated with females. While triglycerides >150 mg/dL and fasting blood glucose of >100 mg/dL were more associated with male patients. CONCLUSION Subclinical Hypothyroidism was present in 22% of study population and more so in females having metabolic syndrome (32%). Hence, it will be worthwhile to screen female metabolic syndrome patients for thyroid function abnormality. Abnormal blood pressure, triglycerides and HDL cholesterol levels were more associated with subclinical hypothyroidism. In our study, all patients of metabolic syndrome had raised hs-CRP levels. Hence, the role of raised hs-CRP with thyroid dysfunction could not be established. KEYWORDS MetS-Metabolic Syndrome, CRP -C-Reactive Protein. HOW TO CITE THIS ARTICLE: Shah P, Patel H, Dosi R. Subclinical hypothyroidism in metabolic syndrome and role of CRP in 50 adult patients. J. Evid. Based Med.