Objectives: The aim of this study was to assess remineralization effects after applying fluoride varnish on children with white spot in maxillary and mandibular anterior teeth using quantitative light-induced fluorescence. Methods/ Statistical Analysis: 56 participants (2-5 years old) were randomly divided into the Fluor protector group (n=28) and the FluorDose group (n=28). An oral examination was performed at baseline, and QLF-D was used for observations on early caries lesion. After applying

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... the assigned fluoride varnish, QLF-D images were reacquired after 2 and 4 weeks. Data were analyzed using one-way ANOVA and t-test with PASW statistics 18.0 (SPSS Inc., Chicago, IL, USA). Findings: Both groups showed a significant decrease in ∆F value from baseline to after 4 weeks (p < 0.05), at which time, Groups I and II showed a decrease of 5.88% and 1.71%, respectively. There was not statistically significant difference between group I and group II. According to QLF-D scores (0, 1, and 2), all groups showed the highest remineralization rate at score 2 after 2 weeks fluoride application. In the results from after 4 weeks, Group I showed the highest remineralization rate at score 2 (13.2%), while Group II showed the highest remineralization rate at score 1 (9.96%). Improvements/Applications: Viscosity and concentration of the fluoride varnish showed that not to affect the remineralization effect. QLF-D is thought to be useful device in observation of early carious lesion in ECC. The enamel surface of white spot maintains a relatively healthy state, but there is loss of minerals in the area. The demineralized areas are seen as a white-colored, dried state 3 . When remineralization is induced on the demineralized enamel, the progression of demineralization stops and recovery back to original state is possible 4 . Clinically, the most widely used treatment for remineralization is topical fluoride therapy 5 . The mechanism of fluoride in caries prevention is well-known as ability to promoting remineralization, increasing the acid resistance, and anti-microbial activity 6 . Fluoride varnish containing 5%