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LncRNA Miat and Metadhedrin maintain a treatment resistant stem-like niche of medulloblastoma cells
Medulloblastoma is a pediatric brain tumor arising from the cerebellum and brainstem that is curable with surgery and aggressive cytotoxic therapy including craniospinal irradiation and chemotherapy. Preclinical models indicate that a small pool of de-differentiated, stem cell-like medulloblastoma cells are resistant to cytotoxic treatment and contribute to medulloblastoma relapse after aggressive therapy. Here, we identify Miat as a Shh and Myc regulated long noncoding RNA (lncRNA) that isdoi:10.1101/2021.09.23.461558 fatcat:beml47ncx5ezdclq5bvvxpsuqu