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The cancer Biomedical Informatics Grid (caBIG) is revolutionizing the way medical researchers share information and collaborate. A key to caBIG's continued success will be interoperability. However, to date, only a single code base (in Java) has been used to create a set of tools and run-time services for caBIG. This paper presents the first significant exploration into the use of Microsoft's .NET Framework and Visual Studio for caBIG. Given its substantial existing community, a .NET-based setdoi:10.1002/cpe.1599 fatcat:w3pxc4txgrdsbnlteo43ynz3ee