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A mechanistic view of human mitochondrial DNA polymerase γ: Providing insight into drug toxicity and mitochondrial disease
2010
Biochimica et Biophysica Acta - Proteins and Proteomics
Mitochondrial DNA polymerase gamma (Pol γ) is the sole polymerase responsible for replication of the mitochondrial genome. The study of human Pol γ is of key importance to clinically relevant issues such as nucleoside analog toxicity and mitochondrial disorders such as progressive external ophthalmoplegia. The development of a recombinant form of the human Pol γ holoenzyme provided an essential tool in understanding the mechanism of these clinically relevant phenomena using kinetic
doi:10.1016/j.bbapap.2010.01.007
pmid:20083238
pmcid:PMC2846211
fatcat:rj2spfofdnbkto77seji254tv4