The purpose of this study was to develop gastroretentive floating bilayer tablets of atenolol. A natural excipient, psyllium husk, was utilized for development of floating layer of bilayer tablet. Tablets were prepared by compression of separate layers of drug release controlling granules and floating granules. All tablets were subjected to buoyancy lag time, floating duration and in-vitro drug release studies. The buoyancy lag time was found dependent on sodium bicarbonate concentration. The

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... esence of psyllium husk was found suitable for maintaining buoyancy of bilayer tablets for long duration without affecting drug release kinetics. Thus psyllium husk inclusion in floating layer of bilayer tablets was improved the floating behaviour of bilayer tablets of atenolol.