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Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics
2016
Cell Reports
Graphical Abstract Highlights d RNAi and CRISPR/Cas9 screens were used to find flavivirus dependencies d The screens recovered host factors involved in endocytosis and heparin sulfation d The EMC is required by DENV and ZIKV in the early stages of replication d These studies give a systems-wide view of human-flavivirus interactions SUMMARY The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of
doi:10.1016/j.celrep.2016.06.028
pmid:27342126
fatcat:kzcyze5irfditcbcvd7awi6aqy