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In oncology, two-dimensional in-vitro culture models are the standard test beds for the discovery and development of cancer treatments, but in the last decades, evidence emerged that such models have low predictive value for clinical efficacy. Therefore they are increasingly complemented by more physiologically relevant 3D models, such as spheroid microtumor cultures. If suitable fluorescent labels are applied, confocal 3D image stacks can characterize the structure of such volumetric culturesdoi:10.1371/journal.pone.0156942 pmid:27303813 pmcid:PMC4909318 fatcat:2tcwxyc4cnhc7pwmlbalforpxq