Dynamics of DNAin vitroevolution withMnt-repressor: Simulations and analysis

Yufeng Yang, Hongli Wang, Qi Ouyang
2003 Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics  
The dynamics of DNA in vitro evolution with Mnt-repressor has been studied numerically and analytically. Based on experimental data and realistic energy landscape for DNA-Mnt-repressor interaction, we investigated the dynamics of DNA in vitro evolution using stochastic simulations. The binding energy of DNA to Mntrepressor was considered to consist of two parts: the DNA sequence specific and nonspecific. The crossover observed in real experiments is numerically recovered. We demonstrate that
more » ... demonstrate that the evolution trajectories are drastically dispersed and no typical evolution passage exists during the evolution. Particularly, Fisher's theorem of natural selection is verified. A theoretical analysis for the evolution is also included.
doi:10.1103/physreve.68.031903 pmid:14524799 fatcat:ro2ivycebvgn5mjdyypbu7j6qy