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New genetic resources for mammalian developmental biologists
2010
F1000 Biology Reports
Preserved Fulltext
The utilization of homologous recombination in embryonic stem cells as a means to generate mice carrying pre-determined modifications of genomic sequences has revolutionized the study of developmental biology. Recognizing the potential efficiencies that can be obtained by high-throughput production at centralized technology centers, a number of large-scale efforts for generating mice with targeted mutations have been funded. These programs are reaching fruition, and a variety of libraries of
doi:10.3410/b2-72
pmid:21173845
pmcid:PMC2989628
fatcat:7vxs2vadtrgvrojtoorkjuy4re