Treatment of Lymphoid Malignancies with Non-myeloablative Stem Cell Transplantation

M.D. Seftel, J. Lavoie, M.J. Barnett, E. Conneally
2002 Hematology  
The traditional approach to allogeneic hematopoietic stem cell transplantation involves the administration of myeloablative preparative regimens. This form of conditioning is associated with a relatively high incidence of regimen-related toxicity. As a result, candidates for allogeneic stem cell transplantation may be excluded owing to advanced age or co-morbid medical illness. Recently, so-called "non-myeloablative" regimens have been introduced, where less intense conditioning therapy is used
more » ... ing therapy is used in an attempt to reduce regimen-related toxicity. In addition, non-myeloablative transplantation takes advantage of the graft-versustumour effect that is characteristic of allogeneic stem cell transplantation. We review the background, available clinical data, and future directions in non-myeloablative stem cell transplantation, and focus on its potential use in the treatment of lymphoid malignancies.
doi:10.1080/1024533021000008209 pmid:12243977 fatcat:t5fcu543z5g6jk5yf7sfxkdwo4