The mechanism of action of thymus-derived polypeptide (t-activin) in experimental emotional stress model: a neurochemical study

N M Kiseleva, A V Novoseletskaya, A N Inozemtsev, V S Kudrin, P M Klodt, V B Narkevich, I V Zimina, V Ya Arion
2011 RUDN Journal of Medicine  
The effects of T-activin, the thymus-derived polypeptide, on the content level of monoamines and their metabolites in frontal cerebral cortex, striatum, hypothalamus, nucleus accumbens and hippocampus of rats under emotional stress conditions using HPLC technique have been studied. The substance was shown to reduce the indices of emotional tension and to improve adaptation in stressful conditions at rats that may be the evidence of the anxiolytic action of T-activin. It may be suggested that
more » ... positive influence of the thymus polypeptide manifested on the serotonin/norepinehrine balance in favor of the first in hypothalamus and frontal cerebral cortex.
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