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Int J Clin Exp Med
Nobiletin, a major polymethoxy flavone, has been demonstrated to exert protective effects on cardivas-cular diseases. However, the effects of nobiletin on pulmonary arterial hypertension (PAH) have not been studied. Herein in this report, PAH was induced by a single monocrotaline (MCT) injection in rats, and then rats were treated with nobiletin for consecutive three weeks. At the end of three weeks, hemodynamic parameters, right ventricular hypertrophy and pulmonary vascular remodeling werefatcat:5la2trlryzflfhryaazllpqaby