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Surprising Phenotypic Diversity of Cancer-associated mutations of Gly 34 in the Histone H3 tail
Sequencing of cancer genomes has identified recurrent somatic mutations in histones, termed oncohistones, which are frequently poorly understood. Previously we showed that fission yeast expressing only the H3.3G34R mutant identified in aggressive pediatric glioma had reduced H3K36 trimethylation and acetylation, increased genomic instability and replicative stress, and defective homology-dependent DNA damage repair (Yadav et al., 2017). Here we show that surprisingly distinct phenotypes resultdoi:10.1101/2020.12.10.419184 fatcat:pisps455srb2dj5bprbkieeam4