Evaluations of echogenicity in gluteal muscle in patients with schizophrenia treated with second generation long-acting injectable antipsychotics: risperidone or aripiprazole

Yuko YASUHARA, Tetsuya TANIOKA, Kensaku TAKASE, Rieko MIKI, Tomoka SAKAMOTO, Kazuhiro OZAWA, Kazushi MOTOKI, Yueren ZHAO, Takaharu AZEKAWA, Rozzano LOCSIN
2018 Neurosonology  
安原 由子 1 谷岡 哲也 1 高瀬 憲作 2 三木 理恵子 3 坂本 朋香 4 小澤 和弘 5 元木 一志 6 趙 岳人 7 阿瀬川 孝治 8 1 1 2 3 4 5 6 7 8 Second generation long-acting injectable antipsychotics (SG-LAIs) injected muscle region show high-echogenicity with acoustic shadowing on B-mode scan. This study aimed to distinguish two specific types of SG-LAIs at the gluteal muscle. Forty-seven patients [risperidone (RLAI): 28 patients, aripiprazole (ALAI): 19 patients] were examined using grayscale histogram analysis of echo-intensities. Pre-and
more » ... iately after (post)-injected SG-LAI region of interest (ROI) was placed on the same sites of gluteal muscle, and the grayscale histograms were recorded. Pre-and post-injected echogenicity values were analyzed using paired t-test, and Pearson's moment correlation coefficient. Mixed effects model regression analysis was performed on variations in average echogenicity from age and medication type. Statistical significance was at 5%. There was no significant correlation between age and average echogenicity of ROI pre-intramuscular (IM) injection (r = 0.26, p = 0.078). In both RLAI and ALAI, the mean echogenicity post-IM injection was significantly higher than pre-IM injection (p < 0.001). With increasing age, the values of echogenicity of post-injection was decreased significantly (p = 0.002). The increasing values of the echo-intensities post-injections of RLAI showed significantly higher than ALAI (p = 0.002). It was considered that administered type of LAI could be identified because each LAI exhibits specific echographically findings, it also will be able to applied clinically.
doi:10.2301/neurosonology.31.7 fatcat:txfl3zep35bclgahk6m2xp7btu