Behçet's disease (BD) is a multisystem vasculitis of unknown origin that involves the parenchymal central nervous system (neuro-BD) in less than 10 percent of patients affecting both brain and spinal cord. We reported a rare case of 21-year-old male patient with NBD-myelitis in the form of neuromyelitis optica (NMO) which treated successfully with cyclophosphamide, with marvelous MRI radiographic regression as no disease activity was detected and the patient reported no adverse event, after six

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... cyclophosphamide cycles, cervical MRI marked regression. This case may be an example for decision making and management in such rare cases.