Cystic Fibrosis%3A Computing the World's First Cure for a Genetic Disease

James Bonnar
2016 Figshare  
Cystic fibrosis (CF) affects millions of people worldwide. In this book we discuss both the technical and non-technical reasons science has been unable to find cures for inherited diseases such as CF, despite the exponential increase in knowledge of disease mechanisms we currently witness. New directions in scientific research and protocols are suggested that may help bring about actual cures for genetic diseases through medicinal gene therapy. A new computational approach, called the omega
more » ... rithm, is developed, implemented and applied to find compounds that could potentially correct the delta F508 mutation responsible for cystic fibrosis. Links to downloadable files, including an extensive chemical reaction database, are given in an appendix to assist the reader with their own further studies. All computer code in the book is written in the Mathematica language.
doi:10.6084/m9.figshare.4104021.v1 fatcat:2j5fwnnzi5eiljegu3d4gremqi