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Immediately after formation of the mature miRNA, the duplex is unwound and loaded onto the RNA-induced silencing complex, which ultimately carries out the silencing of target mRNA. The RISC is a trimeric complex composed of Dicer, TRBP, and a protein of the MicroRNAs (miRNAs) are now recognized as the primary RNAs involved in the purposeful silencing of the cell's own message. In addition to the established role of miRNAs as developmental regulators of normal cellular function, they havedoi:10.3171/2009.10.focus09207 pmid:20043718 fatcat:3j4qo4okezc5jdhwav4ijsenzi