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Scale-up and Process Transfer of Freeze-Drying Recipes
2011
Drying Technology
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This paper proposes a simple and effective methodology for the scale-up and process transfer of freeze-drying recipes. Process modeling allows studying in silico product evolution in a given freeze-dryer, and calculating the operating conditions that results in the same product dynamics in a different equipment. Few experiments are necessary to determine model parameters and to characterize the two freeze-dryers. The problem of the batch nonuniformity and the effect of parameters uncertainty
doi:10.1080/07373937.2011.597059
fatcat:hzqj4qa5u5csdp7v7gwsev56xa