The Impact of Vitamin D in Cancer [chapter]

Khanh vinh quoc Luong, Lan Thi Hoang Nguye
2013 Cancer Treatment - Conventional and Innovative Approaches  
The relationship between vitamin D and cancer has previously been reported in the literature. " systemic review and meta-analysis of prospective cohort studies revealed that a nmol/L increase in the -hydroxyvitamin D OHD levels was associated with an % lower mortality in the elderly population Schöttker et al., . Oncology patients had significantly lower mean serum vitamin D levels than non-cancer primary care patients from the same geographic region Churilla et al., . In a community oncology
more » ... ommunity oncology experience, vitamin D deficiency is widespread in cancer patients and correlates with advanced stage disease Churilla et al., . " high prevalent of vitamin D deficiency has been associated with head and neck cancer Orell-Kotikangas et al., , breast cancer Crew et al., Peppone et al., , vulvar cancer Salehin et al., , prostate cancer Varsavsky et al., , pancreatic cancer Wolpin et al., , gastric cancer Ren et al., , colon and rectal cancer Tangrea et al., , ovarian cancer Lefkowitz et al., , oral cavity and esophagus cancers Lipworth et al., , myelo-proliferative neoplasms and myelo-dysplastic syndromes Pardanani et al., , multiple myeloma Ng et at., , non-Hodgkin's lymphoma Drake et al., , and chronic lymphocytic leukemia Shamafelt et al., . On the other hand, a serum OHD concentration of nmol/L was associated with a % reduction in incidence of cancer, a % reduction in total cancer mortality, and a % reduction in digestive system cancer mortality Giovannucci et al., . Improving vitamin D status may also help lower the risk of colorectal cancer Wu et al., a . In a case-control study, a higher vitamin D intake is associated with a lower risk of esophageal squamous cell carcinoma Launoy et al., . " meta-analysis revealed that an increase of serum OHD by nmol/L was associated with a risk reduction of % for rectal cancer and % for colon cancer Yin et al., . High OHD levels were associated with better prognosis in breast, colon, prostate cancer, and lung cancer relative to patients with lower OHD levels Robsahm et al., Zhou et al., . In a murine model, dietary vitamin D may play an important role as a preventive agent in andro-
doi:10.5772/55324 fatcat:h6c2pyxtsbaldfuo7q4bf535g4