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Functional interaction between Fanconi anemia and mTOR pathways during stalled replication fork recovery
[article]
2020
bioRxiv
pre-print
ABSTRACTFanconi anemia (FA) is a multi-gene genomic instability disorder characterized by cancer predisposition. Clinically, FA patients are diagnosed with bone marrow failure as well as different types of cancer, mainly acute myeloid leukemia and solid tumors. FA genes encode for DNA damage repair proteins. One of the consequences of cellular exposure to DNA damaging agents is that the DNA replication stalls. Once damaged DNA is repaired, replication needs to restart. We have previously
doi:10.1101/2020.01.16.899211
fatcat:vkur7jd2ijc4ffw24ymcahrtui