Inducible NO Synthesis in the Vasculature

Joseph Loscalzo
2001 Arteriosclerosis, Thrombosis and Vascular Biology  
N itric oxide synthesized by endothelial NO synthase (eNOS) is a principal mediator of smooth muscle relaxation in the normal blood vessel. With inflammation, however, inducible NO synthase (iNOS) is expressed in the vessel wall, including the adventitia, 1 and is associated with impaired endothelium-dependent vasorelaxation 2 and impaired vasoconstriction. 3,4 The molecular mechanism(s) underlying these alterations in vasomotor function accompanying inflammation remains unknown, although in
more » ... ro studies suggest that proinflammatory stimuli reduce the expression of eNOS, agonist-mediated cytosolic calcium mobilization, and NO production. 5
doi:10.1161/atvb.21.8.1259 fatcat:oosjnpncifbkfjvkzaqrafhq4y