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Edited by Gianni Cesareni Keywords: Origin of replication Bendability Cleavage intensity Support vector machine a b s t r a c t In this study, we introduced two DNA structural characteristics, namely, bendability and hydroxyl radical cleavage intensity to analyze origin of replication (ORI) in the Saccharomyces cerevisiae genome. We found that both DNA bendability and cleavage intensity in core replication regions were significantly lower than in the linker regions. By using these two DNAdoi:10.1016/j.febslet.2012.02.034 pmid:22449982 fatcat:vxxjkr2ez5az7ar3hrze5bvgie