Neuronal traits are required for glucose-induced insulin secretion

Amar Abderrahmani, Guy Niederhauser, Valérie Plaisance, Jacques-Antoine Haefliger, Romano Regazzi, Gérard Waeber
2004 FEBS Letters  
The transcriptional repressor RE1 silencer transcription factor (REST) is an important factor that restricts some neuronal traits to neurons. Since these traits are also present in pancreatic b-cells, we evaluated their role by generating a model of insulin-secreting cells that express REST. The presence of REST led to a decrease in expression of its known target genes, whereas insulin expression and its cellular content were conserved. As a consequence of REST expression, the capacity to
more » ... e insulin in response to mitochondrial fuels, a particularity of mature b-cells, was impaired. These data provide evidence that REST target genes are required for an appropriate glucoseinduced insulin secretion.
doi:10.1016/j.febslet.2004.04.002 pmid:15135066 fatcat:xvnq2yj7azcddkdbcd3tcilbwi