Parameter Estimation, Sensitivity Analysis and Optimal Control of a Periodic Epidemic Model with Application to HRSV in Florida

Silvierio Rosa, Delfim F. M. Torres
2018 Statistics, Optimization and Information Computing  
A state wide Human Respiratory Syncytial Virus (HRSV) surveillance system was implemented in Florida in 1999 to support clinical decision-making for prophylaxis of premature infants. The research presented in this paper addresses the problem of fitting real data collected by the Florida HRSV surveillance system by using a periodic SEIRS mathematical model. A sensitivity and cost-effectiveness analysis of the model is done and an optimal control problem is formulated and solved with treatment as the control variable.
doi:10.19139/soic.v6i1.472 fatcat:dvwy4mk2jfc3dmy7s3hdj3km3u