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Platelets play a critical role in the regulation of coagulation, one of the essential processes in life, attracting great attention. However, mimicking platelets for in vivo artificial coagulation is still a great challenge due to the complexity of the process. Here, we design platelet-like nanoparticles (pNPs) based on self-assembled peptides that initiate coagulation and form clots in blood vessels. The pNPs first bind specifically to a membrane glycoprotein (i.e., CD105) overexpressed ondoi:10.1126/sciadv.aaz4107 pmid:32766439 pmcid:PMC7385434 fatcat:db4q2rpt6raq7nzfi7m6wswfpe