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Suppressive Mechanisms Induced by Tregs in Celiac Disease

Nastaran Asri, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Mohammad Rostami-Nejad, Mohammad Barzegar, Abdolrahim Nikzamir, Mostafa Rezaei-Tavirani, Mohammadreza Razzaghi, Mohammad Reza Zali, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran (+2 others)
2020 Iranian Biomedical Journal  

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CD is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4 + Teff cells, and these T-cell subsets can cause the intestinal tissue damages. Also, there are additional subsets of CD4 + T cells with suppressor functions. These subsets express the master transcription factor, FOXP3, and include Tr1 cells and CD4 +
more » ... CD25 + Tregs, which are the main population involved in maintaining the peripheral tolerance, preventing the autoimmune diseases and limiting the chronic inflammatory diseases such as CD. The suppressive function of Tregs is important to maintain the immune homeostasis. This paper examined the features and the basic mechanisms used by Tregs to mediate the suppression in CD.
doi:10.29252/ibj.24.3.140 fatcat:dwrjhb4dvrcpjn6vvjsvwxwlyi
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Nastaran Asri, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Mohammad Rostami-Nejad, Mohammad Barzegar, Abdolrahim Nikzamir, Mostafa Rezaei-Tavirani, Mohammadreza Razzaghi, Mohammad Reza Zali, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. "Suppressive Mechanisms Induced by Tregs in Celiac Disease." Iranian Biomedical Journal 24.3 (2020) 140-147