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BSCL2/seipin regulates adipogenesis through actin cytoskeleton remodelling
2013
Human Molecular Genetics
Seipin regulates lipid homeostasis by preventing lipid droplet (LD) formation in non-adipocytes but promoting it in developing adipocytes. Here, we report that seipin interacts with 14-3-3b through its N-and C-termini. Expression of 14-3-3b is upregulated during adipogenesis, and its deletion results in defective adipogenesis without affecting key adipogenic transcription factors. We further identified the actin-severing protein cofilin-1 as an interacting partner to 14-3-3b. Cofilin-1 was
doi:10.1093/hmg/ddt444
pmid:24026679
fatcat:hdxfi4wyazfxdlto7pignsml2m